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20 Renal Effects of SGLT2 Inhibitors in Patients With Diabetes Mellitus In the randomized controlled parallel group RED study of T2D patients (n=44) comparing dapagliflozin or gliclazide over 12 weeks, dapagliflozin reduced measured glomerular filtration rate and reduced filtration fraction without increased renal vascular resistance as measured by insulin- and para-aminohippurate clearance (NCT02682563)

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As these findings are derived exclusively from case reports, they represent very-low-certainty evidence and cannot establish class-level incidence

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